منابع مشابه
IκBα beyond the NF-kB dogma
The NF-κB pathway participates in a myriad of processes including cell differentiation, proliferation, survival, and regulation of the immune response. In mammals there are five NF-κB proteins: p65/RelA, p50, RelB, cRel and p52. All these proteins can form dimers to generate more than a dozen of possible combinations. Different NF-κB dimers bind the DNA at specific κB sites, acting as activator...
متن کاملStructure of an IκBα/NF-κB Complex
Each of the IkB proteins contains six or more 33The inhibitory protein, IkBa, sequesters the transcripresidue-long ankyrin repeats, named for their homology tion factor, NF-kB, as an inactive complex in the cytoto repeats in the erythrocyte protein ankyrin (reviewed plasm. The structure of the IkBa ankyrin repeat domain, in Bork, 1993). Ankyrin, which has 24 such repeats, links bound to a parti...
متن کاملEndocrine Disrupting Contaminants—Beyond the Dogma
Descriptions of endocrine disruption have largely been associated with wildlife and driven by observations documenting estrogenic, androgenic, antiandrogenic, and antithyroid actions. These actions, in response to exposure to ecologically relevant concentrations of various environmental contaminants, have now been established in numerous vertebrate species. However, many potential mechanisms an...
متن کاملHuman Cytomegalovirus Upregulates NF-kB Activity by Transactivating the NF-kB p105/p50 and p65 Promoters
During human cytomegalovirus (HCMV) infection, a series of regulated events take place following virus binding and entry into the cell, including the upregulation of cellular transcription factors, such as NF-kB, which play an essential role in the viral life cycle. We show here that NF-kB message is induced during HCMV infection and that the induction is biphasic, suggesting an initial inducti...
متن کاملNF-kB, Autoimmunity and Mycobacteria
Many autoimmune diseases feature functional or genetic defects that can alter NF-kB function. In an animal model of type 1 diabetes and Sjogren’s syndrome, a defective proteasome prevents NK-kB-induced gene transcription by precluding cleavage of IkBa from NF-kB in the cytoplasm. Polymorphisms in such NK-kB related genes as SUMO4, NOD2, IKBL, IRF-5, TNFAIP3, TNF, TNFR1, TNFR2, IL-10 and DLG-5 h...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Oncotarget
سال: 2013
ISSN: 1949-2553
DOI: 10.18632/oncotarget.1325